Designated registered nurses will be able to prescribe commonly-used medicines from September 20.
Health Minister Jonathan Coleman says that could save a visit to a doctor.
Under the new regulations, the nurses will be able to prescribe from a list of specified medicines.
The Nursing Council will be responsible for ensuring they meet competence standards before they can become designated prescribers.
"The changes mean a suitably trained registered nurse working in a primary care team could treat a person needing medicines for a straightforward condition," Dr Coleman said on Wednesday.
"This has the potential to deliver faster care, reduce double handling and improve access to medicines."