Mexican authorities are searching hotels, hospitals and funeral homes while distributing 100,000 leaflets with recent pictures of Joaquin "El Chapo" Guzman, in a massive manhunt for the fugitive drug lord.
In his second escape in 14 years, Guzman on Saturday (local time) broke out of prison through a 1.5-kilometre tunnel dug under his cell's shower.
The jailbreak was a humiliation for President Enrique Pena Nieto, just 17 months after the kingpin's capture.
The interior ministry said 101 checkpoints have now been placed on the main roads and highways of 21 of the country's 31 states and the capital to find Guzman.
Some 1,250 federal police officers have fanned out in special search units around the Altiplano prison from where he escaped, some 90 kilometre west of Mexico City.
In addition, more than 180 special forces from the police gendarmerie are conducting their own search for the Sinaloa drug cartel kingpin.
Some 8,200 federal police officers are on "maximum alert" in every state, the interior ministry said in a statement.
"More than 100,000 leaflets with recent pictures of the fugitive are being distributed at toll booths," it said.
"Special operations are being conducted to check hotels, hospitals and funeral homes."
Every private flight is being checked at the nation's airports, with a "rigorous inspection of passengers".