Wales has extended Scotland's losing Six Nations championship run to nine matches with second-half tries from Jamie Roberts and George North securing a 27-23 victory.
Lacklustre Wales, second best for an hour under a closed roof at the Principality Stadium in Cardiff, sparked into life when Roberts barged over and then North touched down after a strong diagonal run.
Wales, who rallied from 13-0 down to draw 16-16 with Ireland in their tournament opener last weekend, scored the game's opening try through scrumhalf Gareth Davies but Scotland replied soon after via winger Tommy Seymour.
Three Greig Laidlaw penalties put Scotland 16-13 up midway through the second half before Wales pulled clear. Duncan Taylor's late converted try proved only a consolation.
"Historically we tend to get gradually better as the tournament goes on. That's a bit better than last week, but you've got to give credit to Scotland. The way they're playing they don't deserve to be zero from two matches," Wales captain Sam Warburton told the BBC.
Scotland, beaten 15-9 at home by England a week ago, have not defeated Wales since 2007 and have not won in Cardiff for 14 years.
Wales began with a bang with scrumhalf Davies, who appeared suspiciously offside, crossing after six minutes.
Scotland were hammered 51-3 on their last visit to Cardiff in 2014 when they had Stuart Hogg sent off, and the fullback enjoyed a brighter afternoon until injury forced him out of the game after half an hour.
Despite the loss of their most potent attacking threat, Scotland continued to make metres against a retreating Welsh defence and got reward with two Laidlaw penalties, either side of one from Biggar, to put the Scots 13-10 up at the break.
Having lacked attacking inspiration, winger Tom James' electric 60-metre burst down the flank finally sparked the hosts into life on 58 minutes. Scotland centre Duncan Taylor making a try-saving tackle on the left winger.
The crowd ignited, Wales exerted intense pressure in the next few minutes before Roberts crashed over from close range to put his side ahead for the first time since their early try.
North then made the game safe when he ran in unopposed from the Scotland 22, leaving Vern Cotter's men to wonder just when the next Six Nations win will come.
Meanwhile France burst into life when Maxime Medard's second-half try inspired them to their first victory over Ireland in five years with a 10-9 win in the Six Nations.
Coach Guy Noves, who took over from Philippe Saint-Andre after last year's World Cup, had promised spectacular rugby and Les Bleus did their best to deliver at the Stade de France, scoring the only try with 10 minutes remaining.
Flyhalf Jules Plisson converted, adding to his first-half penalty, while defending champions Ireland's points came from the penalty of Jonny Sexton, who was replaced with a suspected neck problem near the end.
France, who lost 24-9 to the Irish in the World Cup pool phase, now lead the standings with two wins after beating Italy 23-21 in their opening game. Ireland must wait for their first victory after last weekend's 16-16 draw against Wales.
Les Bleus had not beaten Ireland in their last five games, winning for the last time in a World Cup warm-up game in 2011, and they were bothered by the visitors' superiority at the breakdown but they never gave up.
Injury-plagued Ireland took confidence from the return of flanker Sean O'Brien and fullback Rob Kearney. O'Brien, however, appeared to sustain a hamstring injury midway through the first half and was replaced by Tommy O'Donnell.
Sexton kicked the first penalty of the game to put the visitors in front as Ireland played their usual gritty game.
He doubled the tally after France were once again penalised at the ruck.
Dave Kearney left the field with a crushed shoulder after a brutal tackle, with Fergus McFadden taking his place.
France failed to make the most of the rare times they had the ball in the Irish half and the highly unimpressive Teddy Thomas was replaced on the right wing by Hugo Bonneval early in the second half.
Mike McCarthy was carried off on a stretcher after he appeared to be knocked out in a collision of heads with team mate Jack McGrath.
France travel to Wales on February 26 and Ireland go to England the following day.
Reuters
