Jerry Lewis, nicknamed 'The King of Comedy', has died aged 91 of natural causes.
The Nutty Professor star was surrouned by family at his Las Vegas home when he died, the family says in a statement.
Lewis became a household name as Dean Martin's comedy partner in the 1950s, and was even nominated for a Nobel Peace Prize in 1977 for charity work.
His legacy includes more than US$2.5 billion raised for the Muscular Dystrophy Association through an annual telethon he hosted for decades.
Lewis continued to perform stand-up in Las Vegas right up to 2016, after debuting in the city in 1949.
Tributes to Lewis have been posted online by the likes of Jim Carrey, Ellen DeGeneres, Goldie Hawn and Jimmy Kimmel.