Prince Harry and his pregnant wife Meghan Markle are to set up their own household, breaking away from the joint operation they shared with the Harry's elder brother Prince William and his wife Kate Middleton.
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Harry and Meghan, known officially as the Duke and Duchess of Sussex, have shared staff with William and Kate since their marriage in May last year.
Queen Elizabeth has now agreed to allow them to set up a new base at Buckingham Palace this Spring.
"The Duke of Sussex currently has his own private office, which has been supporting the Duchess since the engagement of Their Royal Highnesses in November 2017," Buckingham Palace said in a statement.
"This long-planned move will ensure that permanent support arrangements for The Duke and Duchess's work are in place as they start their family and move to their official residence at Frogmore Cottage."
British newspapers have reported since the end of last year that there had been a rift between the two couples, although there has been no public indication of any feud.
Earlier this week, the foursome appeared on good terms when they appeared together at a Commonwealth Day service in London.
The change comes as former US actress Meghan is due to give birth to her first child with the queen's grandson this Spring.
The couple are also in the process of moving from a cottage in the grounds of Kensington Palace, where William and Kate live, to a new home on the royal family's Windsor Estate.
Frogmore Cottage, part of a royal family residence since the 18th century, is where they held the evening reception after their dazzling wedding ceremony at Windsor Castle.
Harry and Meghan have appointed Sara Latham, a public relations heavyweight and former senior adviser on Hillary Clinton's 2016 US presidential campaign, as their head of communications.
She also worked in the White House under Bill Clinton in the late 1990s when he was American president and was a special adviser to the late Dame Tessa Jowell when she was culture secretary.