Police have seized more than $200,000 of methamphetamine, more than $30,000 cash and other drugs in Queenstown.
The bust was made on Monday morning by Otago Lakes Central Police, with search warrants executed in Queenstown and Cromwell.
Two men, aged 33 and 36, have been arrested and are facing drug-related charges. The 36-year-old is facing charges of possession of methamphetamine for supply.
It comes after another bust in Alexandra.
"Otago Lakes Central Police will continue to focus on the drug trade in the area, especially anyone dealing methamphetamine as it is well-known the damage it does to communities," Detective Senior Sergeant Malcolm Inglis said in a statement.
"Police will not let these individuals sell illicit drugs and accumulate wealth at the expense of the vulnerable members of our community."
Snr Sgt Inglis urged people battling by meth addiction to seek help, adding that police are happy to put people affected by drugs in contact with support agencies.
Where to find help and support:
Shine (domestic violence) - 0508 744 633
Women's Refuge - 0800 733 843 (0800 REFUGE)
Need to Talk? - Call or text 1737
What's Up - 0800 WHATS UP (0800 942 8787)
Lifeline - 0800 543 354 or (09) 5222 999 within Auckland
Samaritans - 0800 726 666
Depression Helpline - 0800 111 757
Suicide Crisis Helpline - 0508 828 865 (0508 TAUTOKO)