Playmaker Christian Lealiifano will make a remarkable return for the Wallabies on Saturday while James O'Connor is also set to make his test comeback against Argentina in Brisbane.
Playmaker Lealiifano will join Will Genia, Marika Koroibete and Kurtley Beale as additions to the starting backline just four tests out from September's World Cup in Japan.
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The 31-year last played for the Wallabies in 2016 and has fought back to top form to earn a return following his battle with leukaemia.
O'Connor's last test was in 2013, and the reformed utility is poised to return off the bench at Suncorp Stadium as coach Michael Cheika continues to assess his World Cup options.
There are five changes to the team that started in last weekend's loss to South Africa in Johannesburg and a further five changes on the bench.
But Samu Kerevi will again partner Tevita Kuridrani in the monster centre pairing used against the Springboks.
Beale replaces Tom Banks at fullback after his brilliant cameo off the bench at Ellis Park and lock Luke Jones has been named on the bench as he eyes his first Test since 2014.
Scott Sio returns from injury to start while fellow prop James Slipper has recovered from his nasty head knock against the Springboks and drops to the bench.
Regular five-eighth Bernard Foley has been left out of the match squad, with Matt Toomua providing cover off the bench.
Fellow squad members Joe Powell, Rob Valetini, Jack Maddocks and Jack Dempsey, will all play club rugby this weekend.
Argentina came within a whisker of defeating New Zealand at home (20-16) last weekend and upset the Wallabies on the Gold Coast last year.
But victories like that have been rare for the Pumas, who are on the six-game losing streak and watched as Australia orchestrated their biggest comeback win in Test history against them in Salta last year.
The Wallabies are also unbeaten in their last five starts at Suncorp Stadium.
Wallabies: 1-Scott Sio, 2-Folau Fainga'a, 3-Sekope Kepu, 4-Izack Rodda, 5-Rory Arnold, 6-Lukhan Salakaia-Loto, 7-Michael Hooper (c), 8-Isi Naisarani, 9-Will Genia, 10-Christian Lealiifano, 11-Marika Koroibete, 12-Samu Kerevi, 13-Tevita Kuridrani, 14-Reece Hodge, 15-Kurtley Beale
Reserves: 16-Tolu Latu, 17-James Slipper, 18-Taniela Tupou, 19-Rob Simmons, 20-Luke Jones, 21-Nic White, 22-Matt To'omua, 23-James O'Connor
Join us for live updates of All Blacks v South Africa from 7:30pm Saturday