Warriors' hooker Issac Luke will miss the Warriors trip to Perth with a shoulder injury.
The 30-year old suffered a shoulder injury during the Warriors 21-14 win over the Bulldogs on Friday and has not recovered in time to make the trip.
With Luke missing the game, it gives youngster Nathaniel Roache the chance to wear the number nine jersey.
Roache came on in the first half against the Bulldogs, replacing Luke and impressing Warriors coach Stephen Kearney.
"It's obviously disappointing that Issac is unavailable for this game but Nate did a great job when he came on against the Bulldogs and this is a real opportunity for him," Kearney said.
"While we were happy to get the win over the Bulldogs last week, there is still plenty of room for improvement.
"The Sea Eagles have been playing good footy and we are really looking forward to the challenge.
"We know there are a lot of Kiwis in Perth so we are hoping to have plenty of support at NIB Stadium this weekend."
Despite Luke missing the game, the Warriors welcome back Kieran Foran who missed the Bulldogs clash with a quad injury suffered during the Warriors clash against the Titans.
Solomone Kata remains unavailable for selection after being given bereavement leave last week to fly home to Tonga following the sudden death of his older brother.
Prop Sam Lisone will also miss Saturday's clash due to a pressing family engagement.
Perth has not been a happy hunting ground for the Warriors, as they have never won a game in Western Australia.
The Warriors lost in golden point last season in Perth, a Daly Cherry-Evans field goal in golden point sealed the 15-14 win for the Sea Eagles.
Warriors squad to face Manly Sea Eagles
1. Roger Tuivasa-Sheck (c), 2. Charnze Nicoll-Klokstad, 3. Blake Ayshford, 4. David Fusitu’a, 5. Ken Maumalo, 6.Kieran Foran, 7. Shaun Johnson, 8. Jacob Lillyman, 9. Nathaniel Roache, 10.Ben Matulino, 11. Bodene Thompson, 12. Ryan Hoffman, 13. Simon Mannering
Interchange: 14. Mafoa’aeata Hingano, 15. Bunty Afoa, 16. Albert Vete, 17. James Gavet, 18. Manu Vatuvei, 20. Ligi Sao, 21. Isaiah Papalii, 22. Mason Lino
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