Romelu Lukaku extended his impressive FA Cup scoring record by netting twice in Manchester United's 2-0 win at Huddersfield Town to earn Jose Mourinho's side a quarter-final tie at home to Brighton & Hove Albion.
The Belgian has scored in each of the three rounds United have played of this year's competition and now has 11 goals from his past 10 FA Cup appearances and 21 in all competitions this season.
Lukaku's first came after three minutes, and the striker scored again in the second half after United mounted a quick counter attack..
Saturday's (Sunday NZ time) fifth-round late kickoff also featured English football's latest video assistant referee (VAR) decision when United's Juan Mata had a goal disallowed after being ruled fractionally offside before the interval.
Red Devils manager Jose Mourinho questioned the need for the VAR in this instance.
"The words of the protocol are something like a clear and obvious situation and for sure it was not a clear and obvious situation," he said.
Terriers manager David Wagner was more blunt.
"Yes, the decision went in our favour but this VAR for me kills the emotion of the game," he said.
"This is why I don't like it but I am not the person who makes the decision."
United midfielder Paul Pogba missed the game due to illness.
West Bromwich Albion's tumultuous week took a final turn for the worse as they were knocked out by Southampton 2-1 at the Hawthorns.
Defeat always seemed likely for West Brom, who are bottom of the Premier League and sacked their chairman and chief-executive on Tuesday (Wednesday NZ time).
They then had four senior players interviewed by Spanish police over the alleged theft of a taxi from outside a fast-food restaurant in Barcelona.
Two of those involved in the incident, Jonny Evans and Gareth Barry, both started against Southampton after issuing a public apology, although Evans was stripped of the captaincy by Albion manager Alan Pardew.
Evans could do nothing to stop Southampton taking the lead through Wesley Hoedt on 11 minutes, with Dusan Tadic adding the second after the interval.
Salomon Rondon quickly countered for West Brom with a superb volley finish.
Southampton earned a quarter-final at either Wigan Athletic or Manchester City, who play on Monday.
Brighton's Jurgen Locadia scored on his debut in the 3-1 win over fourth-tier side Coventry City.
At Hillsborough, both managers bemoaned the replay after second-tier Sheffield Wednesday and Swansea City shared a goalless draw.
The winner of the replay will host Rochdale or Tottenham Hotspur, who play on Sunday.
Leicester City will be home to Chelsea in the other quarter-final.
All games will be played between March 16 and 19.
THE FA CUP QUARTER-FINALS DRAW:
Sheffield Wednesday or Swansea v Rochdale or Tottenham
Manchester United v Brighton
Leicester v Chelsea
Wigan or Manchester City v. Southampton