Manchester City has extended their lead at the top of the Premier League to 17 points as Benjamin Mendy and Gabriel Jesus fired them to a 2-0 win at third-placed Leicester City.
City now need, at most, 11 points from their remaining seven matches to secure their third Premier League title in four seasons.
The effects of the international break were barely noticeable on Pep Guardiola's side, who dominated from the outset, having a Fernandinho strike ruled out for offside before Kevin De Bruyne crashed a free kick against the bar.
Leicester were restricted to the counter-attack but went close to an opener on the stroke of halftime when Jamie Vardy rounded Ederson and slotted the ball home but he was narrowly offside.
City were finally rewarded for their control of the game in the 58th minute when, after keeper Kasper Schmeichel had parried out a Riyad Mahrez shot, Leicester failed to clear a Rodri cross and Mendy cut inside Marc Albrighton and side-footed into the far corner.
De Bruyne was at his very best and it was the Belgian who created the second with a glorious defence-splitting pass to Jesus, who fed Raheem Sterling, the England man taking his time before returning the pass to the Brazilian who poked home.
"It was really good today, especially in the first half when we dominated," said De Bruyne.
"There was one team playing. In the second half they did a bit better, but I think we deserved more goals. Half the team started training on Friday."
City, who have now won 15 straight away games in all competitions, have 74 points from 31 games with Manchester United behind them on 57 from 29 matches and Leicester on 56 from 30.
In the battle for Champions League qualification, Leicester are seven points ahead of fifth-placed West Ham United.
"We didn't show the quality we have got but that comes with a bit of tiredness sometimes," said Leicester manager Brendan Rodgers.
"Our organisation was good but we didn't get through the pitch well at times. If you concede against a team with that much quality they can just hide the ball from you," he added.
Guardiola's side play the first leg of their Champions League quarter-final against Borussia Dortmund on Tuesday.
Jota double helps Liverpool romp to win at Arsenal
Liverpool has finally turned on the style to thrash Arsenal 3-0 and move into fifth place in the Premier League with Diogo Jota netting twice after coming on as a substitute.
While their title is heading to Manchester City, the outgoing champions produced the kind of display that saw them romp to glory last season, albeit against a timid Arsenal.
The only surprise was that it took Juergen Klopp's side until after halftime to make their superiority count.
Jota headed Liverpool in front from Trent Alexander-Arnold's cross in the 64th minute, three minutes after coming on.
Mohamed Salah doubled Liverpool's lead four minutes later before Jota scored from close range in the 81st minute.
Victory moved Liverpool above Tottenham Hotspur and West Ham United and left them only two points behind fourth-placed Chelsea who were thrashed at home by West Bromwich Albion earlier, throwing the top-four battle wide open.
Liverpool have 49 points from 30 games with Arsenal down in ninth place with 42 points after a 12th defeat of the season.
"If we are to think about a higher spot then we have to do our jobs and win every single game," Jota said.
"If we do our job we have a chance (to finish in top four)."
Liverpool have lost an unthinkable eight league games since the turn of the year but the way they dominated Arsenal for 90 minutes suggests they are rediscovering their mojo.
Arsenal just could not live with Liverpool's intensity and could make no headway as they fell to their heaviest margin of defeat in a home league game against Liverpool.
One sweeping move early on saw Sadio Mane's header saved by Bernd Leno while Roberto Firmino drilled another effort just wide after Arsenal were harried into conceding possession.
James Milner wasted another chance for Liverpool before halftime and the pattern continued after the break.
Alexander-Arnold was surprisingly left out of England's squad for the recent World Cup qualifiers, but the right back showed his class with a perfect cross which allowed Jota to steal in and head beyond Leno.
It was Jota's fourth headed goal in his last three games, including three for Portugal.
Four minutes later Fabinho's long pass was not dealt with properly by Gabriel and Salah wriggled through to fire a shot through Leno's legs and move back as leader in the race for the Golden Boot prize with 18 goals.
Alexander-Arnold was involved in Liverpool's third, winning the ball back in a dangerous area before Salah's pass across the area was fired home by Jota.
It could have been worse for Arsenal with Liverpool failing to take several good chances but the visitors will head into Tuesday's Champions League clash with Real Madrid in good heart.
"We don't look at Chelsea or West Ham or whatever because we have to win our games," Klopp said. "But tonight the package was extremely good and that's what you need."
Relegation-threatend West Brom stun Chelsea
Relegation-threatened West Bromwich Albion secured a stunning 5-2 win over 10-man Chelsea at Stamford Bridge on Saturday to hand Thomas Tuchel his first loss as the London club's manager.
West Brom, second-bottom of the table, moved seven points from the safety zone while Chelsea stayed fourth but could be overtaken by West Ham United and Tottenham Hotspur this weekend.
Chelsea were looking to record an eighth consecutive clean sheet but Thiago Silva's sending-off for a second yellow card after a reckless challenge opened the floodgates as West Brom ran riot.
"There's no need to concede five goals when you have our quality," Tuchel told BBC Sport after Chelsea's worst home defeat in nearly 10 years.
"We could not adapt to the situation, which is a surprise as we were leading. We're normally confident enough to defend but we were sloppy and kept making big mistakes. We were punished hard and it's tough to digest."
Chelsea took the lead two minutes before Silva's red card when Marcos Alonso's free kick came off the post and Christian Pulisic scored from the rebound, the American winger's first goal under Tuchel.
West Brom used their numerical advantage to good effect as Matheus Pereira scored two goals in quick succession in first-half stoppage time -- which included an assist from goalkeeper Sam Johnstone -- to put the visitors ahead at the interval.
They struck twice on the counter-attack five minutes apart in the second half, with Callum Robinson volleying home a Darnell Furlong cross before Pereira turned provider for Mbaye Diagne.
Chelsea pulled one back to make it 4-2 when Timo Werner set up Mason Mount for a simple tap-in but West Brom scored their fifth in stoppage time when Robinson chipped onrushing keeper Edouard Mendy.
"People will always look to the fact they went down to 10 men but I thought we started the game brightly and created chances. I thought Thiago Silva was lucky to stay on after the first foul," West Brom manager Sam Allardyce said.
"Our goals were all quality goals, not just the finishing but the build-ups. It's just a bit of a shame we didn't show that quality in some others games but this still gives us a bit of hope."
In the other game, Leeds United winger Jack Harrison credited a sports psychologist with helping him after his outstanding performance in his side's 2-1 win over Sheffield United in the Premier League on Saturday.
Harrison opened the scoring in the first half and then saw his low cross poked home by Blades defender Phil Jagielka for an own goal as Leeds ran out 2-1 winners and moved up to 10th in the table.