American Airlines is cutting international flights by 75 percent as demand collapses.
The announcement came as the airline suspended flights to and from Asia, Australia, Europe, New Zealand and South America.
The suspension will remain in place until May 6.
American Airlines will still operate two flights a day to London and three flights a week to Tokyo.
The airline confirmed it would be parking all but a handful of its widebody fleet leaving more than 200 aircraft out of service.
Other US based major airlines are set to make similar moves with United slashing flights to the United Kingdom.
Domestic carrier Southwest is the only airline still operating a full schedule, but is "seriously considering" cutting flights.
Among cost-cutting measures, U.S. airlines are offering employees voluntary unpaid leave to match staffing with flights.
On Friday it was confirmed US airlines were in talks with the White House and Congress about financial assistance.