A leading US hospital is preparing to offer women uterine transplants, a technology that has been proven in Sweden and could help those struggling with infertility.
The Cleveland Clinic said it will be the first hospital in the US to offer transplanted uteruses to 10 women beginning in the next few months.
The clinical trial is open to women of childbearing age who are unable to become pregnant "because they were born without a uterus, have lost their uterus, or have a uterus that no longer functions", said a hospital statement.
The transplants will come from deceased donors and will be temporary. Each organ will be removed after the recipient is able to bear one or two children.
Sweden's University of Gothenburg achieved its first birth via a transplanted uterus in September 2014.
"To date, the Swedish group has performed nine uterus transplants, achieving five pregnancies and four live births," the Cleveland Clinic said.
The road has been long, however, and the first two international attempts at uterus transplants in Saudi Arabia and Turkey were unsuccessful.
Organ rejection during pregnancy has been a key problem.
"The exciting work from the investigators in Sweden demonstrated that uterine transplantation can result in the successful delivery of healthy infants," said Cleveland Clinic lead investigator Andreas Tzakis.
The approach "is still considered highly experimental," said Tommaso Falcone, an obstetrician and chair of the Cleveland Clinic Women's Health Institute.
The Cleveland hospital has already begun screening potential candidates, ranging in age from 21 to 39.
The babies will be delivered by Caesarean section, and the uterus removed after one to two babies.
Infertility due to uterine problems affects thousands of women around the world, and until now few options have existed other than surrogacy or adoption.