The potential presidency of Oprah Winfrey

Reality TV star versus chat show queen in a race for the White House - an unreal contest that some Americans believe should happen, after Oprah Winfrey's inspirational speech at the Golden Globe awards.

Oprah has always denied presidential aspirations, but the White House has welcomed the challenge.

The chat show star was awarded a lifetime achievement award at the Golden Globes ceremony last night and seized the opportunity to deliver a rousing speech. 

Her words ignited Twitter, with actor and friend Reese Witherspoon saying: "Time is now divided into everything that happened before the speech and everything that will happen after."

For some, it echoed Obama and his "Yes We Can" campaign, and now they want Oprah to follow in his footsteps.

"She has my vote, she has 200 of them," actress Gillian Anderson said on on President Winfrey. "It would be extraordinary, extraordinary."

Long-time partner Stedman Graham fuelled speculation, saying she would absolutely do it, if people wanted her to and CNN's media reporter said Oprah's friends told him she was seriously considering it.

But Oprah has repeatedly denied any presidential plans, telling CBS Good Morning: "There will be no running for office of any kind for me."

But why not? The democratic field is wide open, she's well known and well funded.

In fact, fellow billionaire Donald Trump said in 1999, Winfrey would be his first choice as Vice President:

"If she'd do it, she'd be fantastic, she's brilliant, she's popular... she's a wonderful woman."

Detractors say she lacks political experience, much like the current President, who had also previously rejected running for office - while talking to Oprah herself on her show.

"I don't think I have the inclination - I love what I'm doing, I really like it." 

Could their paths cross again? The White House says bring it on.

Two TV stars dueling to run the world's most powerful country.