UK Labour leader Jeremy Corbyn has tabled a motion of no confidence in Theresa May's government after MPs rejected her Brexit deal.
MPs voted on Ms May's Brexit deal on Tuesday (local time), with 432 votes to 202 - a majority of 230.
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Mr Corbyn addressed the House on Tuesday (local time) saying the rejection of Ms May's deal is the biggest defeat for the government since the 1920s.
He has tabled a no confidence motion in the current Tory government, which has been confirmed and will be debated and voted upon on Wednesday at 7pm (local time).
Ms May said she will return to the EU to consider new plans. She will also hold talks with opposition parties about an alternative approach to Britain exiting the EU.
In a statement to MPs following the vote, she said it is clear that the House does not support the deal she came to with EU officials.
"People, particularly EU citizens who have made their home here and UK citizens living in the EU, deserve clarity on these questions as soon as possible," she said.
Looking ahead, Ms May said if her government survives a no confidence vote, she will then proceed to meet with opposition parties to discuss what they want from a Brexit deal.
"The Government will approach these meetings in a constructive spirit, but given the urgent need to make progress, we must focus on ideas that are genuinely negotiable and have sufficient support in this House."
Donald Tusk, the president of the European Council, said in a statement that he regrets the outcome of the vote, and he urged the UK government to "clarify its intentions with respect to next steps as soon as possible".
"The EU27 will remain united and responsible as we have been throughout the entire process and will seek to reduce the damage caused by Brexit," he said.
"We will continue our preparations for all outcomes, including a no-deal scenario. The risk of a disorderly exit has increased with this vote, and while we do not want this to happen, we will be prepared for it."
He said on Twitter: "If a deal is impossible, and no one wants no deal, then who will finally have the courage to say what the only positive solution is?"
Anti-Brexit politicians have reportedly published proposed legislation to bring about another referendum to ask they public, again, if they want to remain in the EU.