Fifty years after that one small step for man and one giant step for mankind, the moon is back in NASA's sights.
NASA says they'll be back in five years. But after so long away, do they still have the right stuff to make that giant leap again?
The Apollo missions didn't take much longer than a week, but this time the plan is to set up a permanent space pad to stay longer.
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In 2016, NASA's Scott Kelly spent an entire year on the International Space Station, double the record, and pushing his endurance to the limit.
What does his experience tell us about our chances out among the stars?
Kelly was only five years old when Neil Armstrong landed on the moon, but he remembers it well.
"Even at a young age I recall being in awe of this accomplishment," he told The Project on Friday.
"I think it's shown us if we put our minds together if we focus, if we put the resources behind it we can achieve some incredible things," he said.
From his year spent in space, Kelly says the most incredible moments of his life were his space walks
"It's incredibly challenging mentally and physically," he said.
"It is one of the most real and surreal moments of your life when you open that hatch earth is 250 miles beneath you and you're going 1700 miles an hour."
But spending a year in orbit isn't easy.
"You can't go home you have the same people around you and you like those people but some variety would be nice," he told The Project through laughter.
Kelly has some advice for the people who remain behind on Earth, drawing on what he has seen from above.
"You see pollution, you see the depletion of the rainforest and you realise that was caused by us," he said.
"I think we're reaching a crisis. It's easier to take care of Earth, than it is to turn Mars into a new Earth."
Watch the full interview above.