Five young children died early on Sunday (local time) in a house fire in Erie, Pennsylvania in the US, police said.
The residence was also a daycare provider, according to reports, and four of the five children were staying there while their parents worked overnight.
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Local news source WJET reported the victims included four siblings - two girls and two boys - aged 8, 6, 4 and 10 months old.
Lieutenant Szocki, of the City of Erie Police Department, told Reuters an adult at the house was also hospitalised.
"The lady that lived there ran through the fire to get outside," Erie Fire chief Guy Santone told WJET. "She had burned her lungs and probably didn't realise that.
"And she drove herself to [the] hospital, and on the way to the hospital, she crashed her car."
The woman was airlifted to hospital, CNN reports.
The fire, which happened about 1:15am (local time), remained under investigation by police and fire officials, Lt Szocki said.