Donald Trump making 'substantial progress' after coronavirus hospitalisation

US President Donald Trump has made "substantial progress" since he was diagnosed and hospitalised with COVID-19, according to his physician.

Trump confirmed he was infected with the coronavirus early on Friday morning (local time) and he was taken to Walter Reed Medical Centre, a military hospital, later that day.

Trump's press secretary Kayleigh McEnany released a statement from his physician Dr Sean Conley ahead of the President's second night in hospital.

"President Trump continues to do well, having made substantial progress since diagnosis," he said.

"This evening he completed his second dose of Remdesivir without complication. He remains fever-free and off supplemental oxygen."

Trump is being treated with Remdesivir, an experimental antibody cocktail, as well as taking zinc, vitamin D, famotidine, melatonin and a daily aspirin.

Dr Conley said Trump spent Saturday afternoon (local time) conducting business and has been moving around the medical suite "without difficulty".

"While not yet out of the woods, the team remains cautiously optimistic. The plan for tomorrow is to continue observation in between doses of Remdesivir, closely monitoring his clinical status while fully supporting his conduct of Presidential duties."

Trump said in a video earlier in the day he was "starting to feel good", adding that "over the next period of a few days I guess that's the real test.

"We'll be seeing what happens over those next couple of days."

He also praised the doctors and nurses at Walter Reed.

"Tremendous progress has been made over the last six months in fighting this plague. With their help, I am feeling well."