More than 1000 people are dead, entire villages have been wiped out and children are orphaned following the worst earthquake to hit Afghanistan in two decades.
On Wednesday, the deadly magnitude 6.1 earthquake struck Afghanistan's southeast - reducing the province of Paktika to rubble.
According to Afghan officials, more than 1000 people have been killed and about 1500 injured - but these numbers are expected to rise as emergency teams search through the debris and reach remote areas.
"Every street you go, you hear people mourning the deaths of their beloved ones," a journalist in Paktika province told the BBC.
A local farmer told the UK state broadcaster most of the dead were very young children.
Save the Children Afghanistan country director Chris Nyamandi said there have been reports of children sheltering under plastic sheets on the streets as many children are likely to be without clean drinking water, food and a safe place to sleep.
"Children are among the most vulnerable in the wake of natural disasters as they are at greater risk of hunger, dying due to their injuries and contracting infectious diseases," Nyamandi said. "When separated from loved ones or orphaned, they are also at further risk of exploitation and abuse."
An Afghanistan journalist shared on Twitter a photo of a child as young as 3-years-old that is now likely an orphan.
Nyamandi said there are grave concerns for more than 118,000 children who have already endured suffering from Afghanistan's wide humanitarian crisis.
"We're seeing in the face of this disaster how healthcare and public services have been decimated over the last 12 months, and how important it is that governments provide largescale assistance to get basic services - like hospitals - back up and running," Nyamandi said.
Save the Children teams are travelling to the worst-hit areas with emergency supplies, such as tarpaulins, blankets and clothes as well as setting up an emergency cash assistance to families, he said.
"Afghanistan's children have endured years of suffering and [Wednesday's] earthquake in Afghanistan's south-eastern provinces is just another blow to a country already on its knees," Nyamandi said.