Fifteen people have been shot, one fatally, at a packed nightclub in Cincinnati, Ohio and police said they believe at least two shooters may have been involved.
The motive is still unclear, but Cincinnati Assistant Police Chief Paul Neudigate said on Twitter that "there are no indications this incident is terrorism related".
The shooting took place around 1 am when hundreds of people were reported to be at the Cameo Nightlife club, which the Cincinnati Police Department said has had "multiple problems" in the past.
"At this point it's unclear exactly what instigated the shooting," Captain Kimberly Williams said at a televised briefing. "We believe that there were at least a couple of shooters involved."
"Just a lot of chaos when the shots went off," Capt Williams added.
The suspects were at large and police do not have good descriptions of them, in part because witnesses were reluctant to cooperate, Capt Williams told WCPO.
The shooting comes less than a year after a gunman opened fire at a gay nightclub in Orlando, Florida, killing 49 people.
Several of the victims in Cincinnati had life-threatening injuries, WLWT-TV reported on its website, quoting Neudigate, who said hundreds of people were in the nightclub at the time of shooting.
"We are in the middle of a very horrific situation that occurred at the nightclub with multiple victims," Neudigate told NBC News.
"It's going to be a long night for our homicide units to investigate this incident, but right now things are stable."
Cameo Nightlife's Facebook page says it features 'College Fridays' for students 18 and older and 'Saturday's 21+ grown and sexy night'.