Another person is seriously injured.
Four people are hospitalised with injuries ranging from moderate to critical.
It's understood two cars and two trucks have crashed on SH1, trapping a motorist.
A section of East Coast Rd is likely to remain closed for some time.
State Highway 1 is closed while emergency services are at the scene.
Police say they are still looking into the matter.
The motorcycle and car collided in Ruakaka on Thursday evening.
There have now been three crashes in the Bay of Plenty this weekend.
The crash happened north of Taupo.